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This view suggests that semaglutide captures most of the available benefit from incretin-based therapy, and tirzepatides advantage comes from fine-tuning rather than fundamentally different mechanisms

This is especially important after a dose increase or when the patient is also taking medication for diabetes, blood pressure, reflux, constipation, or other chronic conditions

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[DOI] [PubMed] [Google Scholar] 52.Yamada Y., Katagiri H., Hamamoto Y., Deenadayalan S., Navarria A., Nishijima K., Seino Y., PIONEER 9 Investigators Dose-response, efficacy, and safety of oral semaglutide monotherapy in Japanese patients with type 2 diabetes (PIONEER 9): A 52-week, phase 2/3a, randomised, controlled trial